Discovery
Our innovation stems from identifying nature-derived compounds that show selectivity against cancer cells and are safe for healthy tissue. Our extensive research studies demonstrate anti-tumor efficacy, effects against metastasis, sensitization of resistant cancer cells to therapy, and synergy with conventional therapies.
LITERATURE
1. Ling T, Lang WH, Martinez-Montemayor MM, Rivas F. Development of ergosterol peroxide probes for cellular localisation studies. Org Biomol Chem. 2019 May 29;17(21):5223-5229. doi: 10.1039/c9ob00145j. PMID: 31025693; PMCID: PMC6541511.
2. Martínez-Montemayor MM, Ling T, Suárez-Arroyo IJ, Ortiz-Soto G, Santiago-Negrón CL, Lacourt-Ventura MY, Valentín-Acevedo A, Lang WH, Rivas F. Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro. Front Pharmacol. 2019 Feb 19;10:115. doi: 10.3389/fphar.2019.00115. PMID: 30837881; PMCID: PMC6389703.
3. Suarez-Arroyo IJ, Rosario-Acevedo R, Aguilar-Perez A, Clemente PL, Cubano LA, Serrano J, Schneider RJ, Martínez-Montemayor MM. Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models. PLoS One. 2013;8(2):e57431. doi: 10.1371/journal.pone.0057431. Epub 2013 Feb 28. PMID: 23468988; PMCID: PMC3585368.